To evaluate the effect of combination of Nigella sativa and Trigonella foenum-graecum seeds with Glibenclamide on serum triglyceride, HDL, and creatinine levels in type-2 diabetes mellitus patients. Diabetic outpatient clinics of Isra University Hyderabad and Liaquat University of Medical and Health Sciences Jamshoro, from March to August 2008. For this study Type-2 diabetic patients on Glibenclamide, who gave written consent to volunteer in the study, were randomly divided into two groups. Fifty patients in group A (Control Group) were maintained on routine dose of Glibenclamide, while fifty patients in group “B” (Intervention group) were given capsules containing equal amount of combined powder of N-sativa and T. foenum-graecum seeds, in addition to their routine dose of Glibenclamide. Serum triglyceride, HDL, and creatinine level were measured for every patient at the start and after 3 months of therapy. Comparison of the mean values of parameters measured in both the groups showed that serum HDL levels were significantly (P < 0.05) raised in intervention group as against the control, whereas the levels for serum triglycerides was comparable in both the groups. Results also showed that no significant change occurred in serum creatinine level in both the groups. This study provides evidence that the combination therapy of N. sativa and T. foenum-graecum with Glibenclamide is beneficial for type-2 diabetic patients as it increases serum HDL level in these patients.

Keywords : Nigella-sativa, Trigonella foenum-graecum, Glibenclamide, HDL, Triglyceride, Type-2 diabetes mellitus.