Aloe Vera was evaluated for CNS activities in mice and different behavioral activities for anxiety and depression were tested on Exploratory activity, Open field test, Swimming – induced Depression test, Stationary Rod, Cage Crossing and Inclined Plane test. Aloe Vera was administered orally in both sexes of mice and was found to cause significant depression in general as well as exploratory behavioral profiles. The results revealed that Aloe Vera caused reduction of Exploratory and Locomotor activities along with the significant decrease in traction in an inclined plane test. The results suggest that Aloe Vera may have anxiolytic potential with sedative action.

Keywords : Aloe Vera, anxiolytic, Exploratory activity, Locomotor activity, depression.