Overt hypothyroidism and hyperthyroidism may be associated with weight gain and loss. The present study was designed to determine the effects of Carbimazole, an antithyroid drug (ATD) used in the treatment of hyperthyroidism and Grave’s disease, on body weight, weight of Pituitary gland and relative weight of male albino rats and compared it with the effect of Carbimazole plus Thyroxin on body weight, absolute and relative weight of Pituitary gland of male albino rats. An Experimental study conducted in Anatomy Department, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi

Keywords : Hyperthyroidism, hypothyroidism, anterior pituitary gland (adenohypophy-sis), thyroid hormones, absolute weight, relative weight, albino rats.