Ascites is the pathological accumulation of fluid in the peritoneal cavity, associated with many clinical symptoms and had various causes. The descriptive observational study was carried out in admitted patients of Civil Hospital Karachi from April 2011 to June 2011. This study was conducted to determine the frequency of major causes and important clinical findings in Ascitic patients. All the admitted patients in medicine wards with the presentation of Ascites were included in this study. The data was collected on a Performa having questions regarding basic patient information, laboratory reports, result of clinical examination and clinical findings. Verbal informed consent was taken and confidentiality was maintained. A total of eighty eight (88) ascitic patients of mean age 50.75±15.845, were evaluated during three months. It was slightly more common in females as compared to males. Most common fluid present in the peritoneal cavity was of transudative type as compare to exudative fluid. Common causes of Ascites were Hepatitis C (53.4%), Hepatitis B (15.9%), chronic renal failure (4.5%) and T.B peritonitis (2.3%). Major co-morbid symptoms of ascitic patients were abdominal pain (52.3%), fever (47.7) and altered level of consciousness (36.4%). Data entry and analysis were done through SPSS 19. A large number of cases of Ascites were due to Hepatitis C and Hepatitis B. For the management of these diseases media and NGOs should come forward and create the awareness regarding these deadly problems.

Keywords : Ascites, Transudative, Exudative, Albumin gradient.