ARTICLE ABSTRACT :

 

Abstract

This study aimed to evaluate the relative effectiveness of two different oral iron regimens on hematological parameters in anemic pregnant women. Study was longitudinal & randomized .Total 160 anemic women attending outpatient clinic of a teaching hospital, were enrolled in the study. Daily group (n=80) received 200 mg ferrous sulphate daily for 12 weeks. Twice weekly group (n= 80) received 200 mg ferrous sulphate twice weekly for 12 weeks. Hemoglobin concentration (Hb conc.), Red blood cell (RBC) count, Red cell indices and reticulocyte count were assessed to compare the effectiveness of daily verses twice weekly iron supplements. In this study 90% (n=72 ) women in daily and 85% (n=68) women in twice weekly group completed the study period. All parameters showed significant improvement for both treatment groups. Hb , hematocrit and RBC count showed a non significant better response in twice weekly group (P value > 0.05). Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC), and reticulocyte count showed a significant better response in twice weekly group (P value <0.05). Mean corpuscular volume (MCV) showed a significant better response in daily group. From the results it can be concluded that twice weekly iron supplementation is equally effective to treat anemia during pregnancy. Daily iron results in greater increase in MCV which might be an additional cause of physiological macrocytosis.


Keywords : Iron deficiency anemia, intermittent iron, macrocytosis, oral iron, pregnancy.